Directional deep brain stimulation contacts provide greater spatial flexibility for therapy than traditional ring-shaped electrodes, but little is known about longitudinal changes of impedance and orientation. We measured monopolar and bipolar impedance of DBS contacts in 31 patients who underwent unilateral subthalamic nucleus deep brain stimulation as part of a randomized study. At different follow-up visits, patients were assigned new stimulation configurations and impedance was measured. Additionally, we measured the orientation of the directional lead during surgery, immediately after surgery, and (...) 1 year later. Here we contrast impedances in directional versus ring contacts with respect to local anatomy, active stimulation contact, and over time. Directional contacts display larger impedances than ring contacts. Impedances generally increase slightly over the first year of therapy, save for a transient decrease immediately post-surgery under general anesthesia during pulse generator placement. Local impedances decrease at active stimulation sites, and contacts in closest proximity to internal capsule display higher impedances than other anatomic sites. DBS leads rotate slightly in the immediate postoperative period but otherwise remain stable over the following year. These data provide useful information for setting clinical stimulation parameters over time. (shrink)

Introduction: Although deep brain stimulation often improves levodopa-responsive gait symptoms, robust therapies for gait dysfunction from Parkinson's disease remain a major unmet need. Walking speed could represent a simple, integrated tool to assess DBS efficacy but is often not examined systematically or quantitatively during DBS programming. Here we investigate the reliability and functional significance of changes in gait by directional DBS in the subthalamic nucleus.Methods: Nineteen patients underwent unilateral subthalamic nucleus DBS surgery with an eight-contact directional lead in the most (...) severely affected hemisphere. They arrived off dopaminergic medications >12 h preoperatively and for device activation 1 month after surgery. We measured a comfortable walking speed using an instrumented walkway with DBS off and at each of 10 stimulation configurations at the midpoint of the therapeutic window. Repeated measures of ANOVA contrasted preoperative vs. maximum and minimum walking speeds across DBS configurations during device activation. Intraclass correlation coefficients examined walking speed reliability across the four trials within each DBS configuration. We also investigated whether changes in walking speed related to modification of step length vs. cadence with a one-sample t-test.Results: Mean comfortable walking speed improved significantly with DBS on vs. both DBS off and minimum speeds with DBS on. Pairwise comparisons showed no significant difference between DBS off and minimum comfortable walking speed with DBS on. Intraclass correlations were ≥0.949 within each condition. Changes in comfortable walk speed were conferred primarily by changes in step length.Conclusion: Acute assessment of walking speed is a reliable, clinically meaningful measure of gait function during DBS activation. Directional and circular unilateral subthalamic DBS in appropriate configurations elicit acute and clinically significant improvements in gait dysfunction related to PD. Next-generation directional DBS technologies have significant potential to enhance gait by individually tailoring stimulation parameters to optimize efficacy. (shrink)

Optimistic predictions that genetic and genomic testing will provide health benefits have been tempered by the concern that individuals who receive their results may experience negative psychosocial outcomes. This potential ethical and clinical concern has prompted extensive conversations between policy‐makers, health researchers, ethicists, and the general public. Fortunately, the psychosocial consequences of such testing are subject to empirical investigation, and over the past quarter century, research that clarifies some of the types, likelihood, and severity of potential harms from learning the (...) results of the testing has accumulated. I aim to provide an overview of the findings of this research by looking at selected systematic reviews. This will convey the gist of the literature’s quality and coverage, reveal gaps in existing knowledge, and highlight promising areas for future scholarship. (shrink)

In an earlier paper on this topic, ‘Eupatridai, Archons, and Areopagus,'3 I was primarily concerned to recover the views of Aristotle, as expressed in the ‘Αθ. πολ., on such elements of Attic Society as Eupatridai, Gennetai, etc. I sought to establish that to him at least these two were not identical: that, more precisely, he recorded two stages of development— ‘Ion’: in whose day the whole body of Athenians was composed of Gennetai, while Eupatridai had not yet been created. ‘Theseus’: (...) who created the Eupatridai—distinguishing them, as a Third Estate, from those two Estates which had hitherto, since Ion, composed the body of Athenians. (shrink)

The purpose of this paper is to put forward the hypothesis that the author of ‘Herodes περ πολιτας is Kritias. The speech bears Herodes’ name: did Herodes' well-known interest in Kritias amount to the transcription of a whole speech? The speech concerns Thessalian affairs at approximately the time when Kritias was in Thessaly: is it exactly the time? and is the tone what we would expect Kritias' tone to be? We have much description of Kritias' prose style, and a few (...) verbatim fragments: does the style of this speech correspond? (shrink)

Communicative Understandings of Women's Leadership Development: From Ceilings of Glass to Labyrinth Paths, edited by Elesha L. Ruminski and Annette M. Holba, weaves the disciplines of communication studies, leadership studies, and women's studies to offer theoretical and practical reflection about women's leadership development in academic, organizational, and political contexts. This work claims a space for women's leadership studies and acknowledges the paradigmatic shift from discussing women's leadership using the glass ceiling to what Eagly and Carli identify as the labyrinth of (...) leadership. (shrink)

As a preliminary to an estimate of the work of Kleisthenes, I have sought in this paper to constate certain facts about the nature of the evidence.

The Spartan Rhetra quoted by Plutarch in Lyc. vi. 2 consists of some thirty-seven words in an archaic Dorian or near-Dorian dialect: Plutarch says it was an oracle, and that later an extra clause was added by the kings Polydoros and Theopompos; he quotes this ‘added clause’ in vi. 8. I believe this Rhetra was not an oracle but an act of the Spartan Ekklesia; and I suspect that the ‘added clause’ was not added, but is an integral part of (...) the original act. But for our first objective this opinion matters less than Plutarch's opinion. Our first objective must be to recover Plutarch's text : and to do that, we must understand his interpretation. (shrink)

This paper is a by-product of two systematic inquiries: one into the Strategia and Strategoi of the fifth century, the other into the military expenditure during the Peloponnesian War. The two inquiries cannot be kept distinct, and both have largely to depend on a minute study of the financial inscriptions.

Hiller vonGaertringen says of this inscription: ‘Lapis in obscuro loco collocatus est. In ectypis nihil fere dispeximus … Lectio e Koehlero et Velseno componenda est.’ I did not find the stone till my last morning in Athens: it is E.M. 6600; it is extremely illegible, and I had not time to move it to a really good light. But there are a few things to add, and the length of line can, I believe, be determined.

I argued in § II. that in the lost chapters of the θηναων Πολιτεα Aristotle recorded the creation by Theseus of the Eupatrid Order, from whom the Archons were chosen: that this tallies with Thuc. II. 15: that Thucydides further suggests that the continuous existence of the Areopagus Council dates from the same time: that finally Council and Order stand to each other as patres and patricii did in Rome.

Wilamowitz denies that there was ever any definite status of Nobility in Athens: his reason is, that Solon says nothing of such a thing. E silentio and very dangerous: and in fact a remnant of Privilege of Nobility survived into the fourth century at least; ϕυλοβαασιλεῖς ἐξ Eὐπατριδῶν. This puts it beyond question that Eupatrid-hood was capable of definition, and carried privilege.

Many developing and transitional countries have grown faster than advanced countries in the past decade, resulting in a shift in the distribution of world income in their favor. China is now the second largest economy in the world, behind the United States and ahead of Japan. As the relative economic weight of China and several others has come to match or exceed that of the middle-ranking G7 economies, the world economy has shifted from “unipolar” toward “multipolar,” less dominated by the (...) G7. How is this change being translated into changes in authority and influence within multilateral organizations like the G20, the World Bank, and the International Monetary Fund? Alarm bells are ringing in G7 capitals about G7 loss of influence. According to a WikiLeaks cable from the senior U.S. official for the G20 process, from January 2010, “It is remarkable how closely coordinated the BASIC group of countries [Brazil, South Africa, India, China] have become in international fora, taking turns to impede US/eu initiatives and playing the US and EU off against each other.” This essay suggests that the shift in power is much smaller than the headlines or private alarm bells suggest. The United States remains the dominant state, and the G7 states together continue to exercise primacy, but now more fearfully and defensively. China is split between asserting itself as “the wave of the future” and defending itself as too poor to take on global responsibilities. The combination of G7 defensiveness and emerging states’ jealous guarding of sovereignty produces a spirit of Westphalian assertion in international fora, or “every state for itself.” On the assumption that the world economy is in a transitional period, the article suggests reforms in the G20 and the World Bank that would boost their role and legitimacy as multilateral organizations in a more multipolar world. (shrink)

International child rights law has the potential to change the way children are viewed and engaged by all social actors. It provides a child-centered perspective on all areas of children’s lives, including research with neonates. It differs from some bioethical perspectives by clearly articulating affirmative obligations owed to children and requiring rigorous monitoring mechanisms. The CRC’s focus on affirmative obligations and establishment of monitoring mechanisms provide additional useful elements that are not present in the dominant form of American pediatric bioethics.An (...) in-depth introduction to child rights and the U.N. Convention on the Rights of the Child is presented by Lansdown.. (shrink)

This famous decree, which is the earliest Athenian decree preserved on stone, is printed e.g. by Hiller in IG. i. no. i, and with a materially different text by Tod in SGHI. no. II. A small new fragment was published in Hesperia, vii. 264. Restorations continue to differ widely and fundamentally. In Hesperia, x. 301–7, Meritt has discussed recent suggestions, and has submitted his own text on p. 307; on p. 305 is a drawing by Raubitschek of the whole monument (...) on the basis of Meritt's text. (shrink)

Plutarch concludes his chapter on the Rhetra with six lines of Tyrtaios: φοβου κοςσαντες Πυθωνθεν οκαδ' νεικαν1 μαντεας τε θεο κα τελεντ' πεα ρχειν μν βουλῦς θεοτιμτους βασιλας οσι μλει Σπρτας μερεσσα πλις πρεσβτας τε γροντας, πειτα δ δημτας νδρας πθεαις τραις ντααπαμειβομνους. These lines are quoted to confirm Plutarch's statement, that the Kings who added the last clause to the Rhetra ‘persuaded the city [to accept this addition] on the grounds that it was part of the God's command'. On (...) Plutarch's view, the two Kings added an extra clause to an oracle, and justified their action by alleging that Delphi had authorized the clause. It is not immediately obvious how Tyrtaios’ lines confirm this view. The Delphic utterance whose substance is given in lines 3–6 approximately paraphrases parts of Clauses I and I I , but where is Clause III ? The burden has to be borne by the one word εθεαις: ‘the Kings and gerontes shall initiate business, the demos shall reply with undistorted rhetrai’ or ‘shall respond to the rhetrai without distorting them’ . If εθεαις is given enough weight, the oracle which Tyrtaios quotes may be held to forbid the ‘excessive amendment’ against which Clause III was aimed. (shrink)

In the foregoing parts of this paper I have sought, first to recover Plutarch's text of the Rhetra, which I believe to be also Aristotle's text. It is evident that Aristotle knew and commented on this Rhetra: I take it as my hypothesis that his account of it in his Spartan Constitution was substantially the same as what Plutarch gives us.

Bullot & Reber (B&R) put forth a design stance to fuse psychological and art historical accounts of visual thinking into a single theory. We argue that this aspect of their proposal needs further fine-tuning. Issues of transgression and coherence are necessary to provide stability to the design stance. We advocate looking to Art Education for such fundamentals of picture understanding.

Sound-producing movements in percussion performance require a high degree of fine motor control. However, there remains a relatively limited empirical understanding of how performance level abilities develop in percussion performance in general, and marimba performance specifically. To address this issue, nine percussionists performed individualised excerpts on marimba within three testing sessions spaced 29 days apart to assess early, intermediate, and late stages of motor learning. Motor learning was quantified via analyses of both the temporal control of mallet movements, and the (...) spatial variability of upper-limb movements. The results showed that temporal control of mallet movements was greater in the intermediate compared to the early learning session, with no significant additional improvements revealed in the late learning session. In addition, spatial variability in the left and right elbows decreased within the intermediate compared to the early learning session. The results suggest that temporal control of mallet movements may be driven by reductions in spatial variability of elbow movements specifically. As a result, this study provides novel evidence for kinematic mechanisms underlying motor learning in percussion which can be applied towards enhancing musical training. (shrink)

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Late in 1990, the Center for the Study of Ethics in the Professions at Illinois Institute of Technology (lIT) received a grant of more than $200,000 from the National Science Foundation to try a campus-wide approach to integrating professional ethics into its technical curriculum.! Enough has now been accomplished to draw some tentative conclusions. I am the grant's principal investigator. In this paper, I shall describe what we at lIT did, what we learned, and what others, especially philosophers, can learn (...) from us. We set out to develop an approach that others could profitably adopt. I believe that we succeeded. (shrink)

This book provides practical and research-based chapters that offer greater clarity about the particular kinds of teacher reflection that matter and avoids talking about teacher reflection generically, which implies that all kinds of reflection are of equal value.